In Underworld 6: Rise of the Vampire, Kate Beckinsale reprises her role as Selene, the iconic Death Dealer. The movie picks up several years after the events of Blood Wars. Vampires and Lycans are still locked in a brutal war, but a new and more dangerous threat emerges—an ancient vampire elder, Alaric, who has been awakened after centuries of slumber. Alaric, played by a menacing new actor, believes that vampires have lost their rightful dominance and aims to rebuild a pure-blooded vampire empire.

Selene, now a more powerful and wiser warrior, is living in relative peace, raising Eve, her daughter who possesses both vampire and Lycan abilities. However, the fragile peace between the vampire covens and the remaining Lycans is shattered when Alaric begins slaughtering both factions to consolidate power. His plan involves resurrecting an army of ancient vampires using forbidden magic to cleanse the world of Lycans and all impure bloodlines.

Selene is reluctantly called back into the fray when Alaric’s forces target Eve, seeing her as a threat due to her hybrid nature. Selene and Eve go on the run, and their journey takes them deep into hidden vampire territories, where Selene uncovers the truth about her own bloodline, which holds the key to stopping Alaric. They also encounter an unexpected ally in a rogue Lycan pack leader, played by a new supporting actor, who seeks to stop the extinction of Lycans.